First, congratulations on throwing off the shackles of lame animu.
Second, my advice would be to start with Space Ghost, Aqua Teen & Sealab, and if you can see it, Frisky Dingo. Also, see the Korgoth pilot at least once.
Those are the most accessible of the originals and don't really go out of their way to visually offend. From there you can go to the more esoteric stuff like Tom Goes to the Mayor, 12 Oz Mouse, etc. But that's far more of an acquired taste. (I liked Tom but couldn't stand Mouse myself)
This Saturday night, it's a heavyweight collision! Newly crowned UFC Heavyweight Champion Junior Dos Santos, fresh off of his 1st round knockout victory over Cain Velasquez on Fox, returns to the Octagon to battle submission specialist Frank Mir in an all heavyweight card! Cain attempts to bounce back from his devastating loss against Brazilian wrecking machine Antonio "Bigfoot" Silva! Plus, Jason "Mayhem" Miller returns on the FX Prelim show to battle CB Dolloway! The action starts 8pm on FX and 10pm on PPV! I mean, what the hell else would you watch?