Maybe instead of Adam and Eve, it could be Adam and Steve. Steve goes to Frankenstein to have a sex change operation so Adam and the first woman in history could populate the garden of Eden (Maybe Victor could splice several female mythological creatures in order for the man to be able to carry a baby and thus making puns of the nature of women), but Adam refuses to share his seed because he is a homosexual (suggesting homosexuality is part of mankind's nature) so the woman Steve sleeps with an ape having several hybrid children (finally bringing in the missing link which catalyzed the evolution of man). maybe there can be some invention of the wheel and discovery of fire jokes with the half man half ape children as well.
well that was fun to conceptualize -thanks viperxmns for the inspiration.