Jazmine is probably the person Huey cares about most outside of his immediate family. Throughout the seasons there have been signs that he does, in fact, value/respect her...handing her his scarf during the lemonade episode, letting her be his apprentice during "The Passion of Uncle Ruckus," having her help him fix the generator, inviting her to his house during the epidemic, etc. His frustration with her was more in season 1, and by season 3 he is very rarely annoyed with the gal, even when the others around him (namely, Riley) seem to be.
I'm not sure if Jazmine likes Huey in a romantic sense...they're 10 after all, lol. But she does look up to him, especially in these later episodes, and admires him to a certain extent. I think Jazmine is the character that has developed the most over the three seasons--from a naive crybaby in season 1 to her current, more mature state (probably from Huey's influence, and also from just growing up).
If they were older, I'd definitely say this pairing contains significant potential, since Jazmine is prob the girl Huey cares about most (as she is the only other individual his age he even talks to), and vice versa. Sometimes I wish McGruder would create a "flash-forward" episode, where we see what happens to the characters when they're older, lol. But I also like the show as it is. As things currently are, I think it's enough to know that Huey and Jazmine are the most important members of the opposite sex to each other right now...not necessarily in a romantic sense (as they are still kids), but I think this is somewhat indicative.