The Office, the American version I'm familiar with anyway, portrays that categorical workplace tension pretty well at times. People see the humor and say, "oh look at that office setting. I have worked in an office. I know that feel." Most of the uncomfortability is derived from Michael Scott's insensitive comments to people in his branch, the kind of comments that would get you fired in an instant in real life. Michael is a self-proclaimed comic-genius with boldness and obliviousness and he only stops when it's too late. But I wouldn't say there's anything inherently childish about The Office's brand of humor, other than Michael's need to be needed and liked.
The difference between The Office's type of awkward and Tim & Eric's type of awkward is with The Office you know it's just a show and doesn't extend into real life. While with Tim & Eric (who basically play stylized versions of themselves), people are more often left asking, "Wait, what did I just watch, why am I watching this, are they serious, what?" There's not always something clearcut you can point at to bridge what you're seeing on Tim & Eric to familiar, real-life experiences.
But take Casey & His Brother, for example. Those sketches impact the viewer on a visceral level. It's a comedy show, but the set-up and execution of the sketch defies what would regularly constitute as A Joke. You want to turn away. It's gross. It's repulsive. It's affected you. It appeals to you on an emotional level.
Tim & Eric nurture the mystery of their intentions better, partly because with what they do laughter is not always the only appropriate response. Tim and Eric are more emotionally-assaulting and challenging.
You know, that's a reaallly incredible synopsis. I would say the man happens to be pure evil.
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