Honostly my oppinion of the next season is this.
Molotov and Monstroso are not dead. There is no way Molotov would want to just die like that in the end. Maybe it is to trick Brock into thinking she is dead.
24 is dead because in operation P.R.O.M, after being identified as 24, he turns to Monstroso's henchman and tells him he has "bad news". Plus the henchman stood up from the pile of dead bodies.
I feel that 21 definitely quit the Monarch because in 4.5 Gary was getting constantly mad at everything. I think its possible he joins Sphynx but i'm not sure where Sphynx will be now that Hunter is head od OSI.
If 21 does quit the Monarch's crew, I don't see how they can show as much of the Monarch as they usually do. More than a little of his apperances in season 4 were sideline to 21. And if he leaves, they will want to focus on him more to establish his intensions.
If Sphynx Disbands that means the Brock has 2 (most likely) directions. Either he is back at the OSI, or he goes back to being Dr. Ventures body guard. If he becomes the body guard, who knows what Sgt. Hatred would do.
I don't think that the Monarch's hatred for Venture will be revealed until their final season of the show and it will probably be done in a special.
I hope they go into how Jonas Venture was killed. That has been bothering me and while it is an important piece of Rusty's background, I don't feel it is that important to the show overall. He died and Rusty is a failure in his place.
I also want them to bring J.J back.
"If life gives you lemons. Throw them back at life and see if it makes the same mistake twice"
"Your like steamed vegetables only smarter"